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Article

Functional assessment of CYP3A4 allelic variants on lidocaine metabolism in vitro.

Drug design, development and therapy - 1 Jan 2017

Fang Ping, Tang Peng-Fei, Xu Ren-Ai, Zheng Xiang, Wen Jian, Bao Su-Su, Cai Jian-Ping, Hu Guo-Xin

Abstract excerpt

AIM: Human cytochrome P450 3A4 is the most abundant isoform of P450 enzyme in the liver. It plays an important role in the metabolism of wide variety of xenobiotic and endogenous substrates. So far, there are few reports about the functional characterization of CYP3A4 variants in terms of specific substrates. The aim of this study was to systematically investigate the genetic polymorphisms of 23 CYP3A4 alleles...

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Identifiers

PMID: 29263648
DOI: 10.2147/DDDT.S152366
PMCID: PMC5724423

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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