Article
The CYP3A4*18 allele, the most frequent coding variant in asian populations, does not significantly affect the midazolam disposition in heterozygous individuals.
Drug metabolism and disposition: the biological fate of chemicals - 1 Nov 2007
Lee Su-Jun, Lee Sang Seop, Jeong Hye-Eun, Shon Ji-Hong, Ryu Ji-Young, Sunwoo Yu Eun, Liu Kwang-Hyeon, Kang Wonku, Park Young-Ju, Shin Chi-Mann, Shin Jae-Gook
Abstract excerpt
The objective of this study was to identify CYP3A4 variants in Koreans and to characterize their functional consequences in vitro and in vivo. Four single nucleotide polymorphisms were identified in 50 Koreans by direct DNA sequencing. In an additional genotyping using 248 subjects, CYP3A4(*)18 was confirmed as the most frequent coding variant in Koreans at 1.7%, and its frequency was similar to that of Asians,...
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