Article
Functional Characterization of 40 CYP3A4 Variants by Assessing Midazolam 1'-Hydroxylation and Testosterone 6β-Hydroxylation.
Drug metabolism and disposition: the biological fate of chemicals - 1 Mar 2021
Kumondai Masaki, Gutiérrez Rico Evelyn Marie, Hishinuma Eiji, Ueda Akiko, Saito Sakae, Saigusa Daisuke, Tadaka Shu, Kinoshita Kengo, Nakayoshi Tomoki, Oda Akifumi, Abe Ai, Maekawa Masamitsu, Mano Nariyasu, Hirasawa Noriyasu, Hiratsuka Masahiro
Abstract excerpt
CYP3A4 is among the most abundant liver and intestinal drug-metabolizing cytochrome P450 enzymes, contributing to the metabolism of more than 30% of clinically used drugs. Therefore, interindividual variability in CYP3A4 activity is a frequent cause of reduced drug efficacy and adverse effects. In this study, we characterized wild-type CYP3A4 and 40 CYP3A4 variants, including 11 new variants, detected among 4773...
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