Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Defective activity of recombinant cytochromes P450 3A4.2 and 3A4.16 in oxidation of midazolam, nifedipine, and testosterone.

Drug metabolism and disposition: the biological fate of chemicals - 1 Nov 2008

Miyazaki Mitsue, Nakamura Katsunori, Fujita Yukiyoshi, Guengerich F Peter, Horiuchi Ryuya, Yamamoto Koujirou

Abstract excerpt

Cytochrome P4503A4 (CYP3A4) is the most abundant cytochrome P450 in adult human liver and small intestine and oxidizes numerous clinically, physiologically, and toxicologically important compounds. The metabolic activity of CYP3A4 in patients varies at least 10-fold in vivo, and CYP3A4 genetic variants are considered one of the causes of individual differences. The cDNAs for the CYP3A4(*)2 (S222P), (*)7 (G56D),...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Catalysis
Share to Cytochrome P-450 CYP3A

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Isoenzymes

Share to Microsomes, Liver

Share to Midazolam

Share to Nifedipine

Share to Oxidation-Reduction

Share to Testosterone

Source

Identifiers

PMID: 18669585
DOI: 10.1124/dmd.108.021816

Genes

TST

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Defective activity of recombinant cytochromes P450 3A4.2 and 3A4.16 in oxidation of midazolam, nifedipine, and testosterone.PMID 18669585Read ↗

Functional Characterization of 40 CYP3A4 Variants by Assessing Midazolam 1'-Hydroxylation and Testosterone 6β-Hydroxylation.Semantic proximity Read ↗

Functional characterization of CYP3A4.16: catalytic activities toward midazolam and carbamazepine.Semantic proximity Read ↗

Identification of variants of CYP3A4 and characterization of their abilities to metabolize testosterone and chlorpyrifos.Semantic proximity Read ↗

Identification and Functional Assessment of Eight CYP3A4 Allelic Variants *39-*46 Detected in the Chinese Han Population.Semantic proximity Read ↗

Comparison of cytochrome P450 2D6 and variants in terms of drug oxidation rates and substrate inhibition.Semantic proximity Read ↗

CYP3A4*16 and CYP3A4*18 alleles found in East Asians exhibit differential catalytic activities for seven CYP3A4 substrate drugs.Semantic proximity Read ↗

Role of P34S, G169R, R296C, and S486T Substitutions in Ligand Access and Catalysis for Cytochrome P450 2D6 Allelic Variants CYP2D6*14A and CYP2D6*14B.Semantic proximity Read ↗

Functional characterization of allelic variants of polymorphic human cytochrome P450 2A6 (CYP2A6*5, *7, *8, *18, *19, and *35).Semantic proximity Read ↗

Genetic findings and functional studies of human CYP3A5 single nucleotide polymorphisms in different ethnic groups.Semantic proximity Read ↗

CYP2D6 Allelic Variants *34, *17-2, *17-3, and *53 and a Thr309Ala Mutant Display Altered Kinetics and NADPH Coupling in Metabolism of Bufuralol and Dextromethorphan and Altered Susceptibility to Inactivation by SCH 66712.Semantic proximity Read ↗

Functional characterization of five CYP2C8 variants and prediction of CYP2C8 genotype-dependent effects on in vitro and in vivo drug-drug interactions.Semantic proximity Read ↗

In Vitro Assessment of the Allelic Variants of Cytochrome P450Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.