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Article

Functional evaluation of vandetanib metabolism by CYP3A4 variants and potential drug interactions in vitro.

Chemico-biological interactions - 1 Dec 2021

Han Mingming, Zhang Xiaodan, Ye Zhize, Wang Jing, Qian Jianchang, Hu Guoxin, Cai Jianping

Abstract excerpt

AIM: To investigate the enzymatic properties of cytochrome P450 3A4 (CYP3A4) variants and their ability to metabolize vandetanib (VNT) in vitro, and to study potential drug interactions in combination with VNT. METHOD: Recombinant CYP3A4 cell microsomes were prepared using a Bac-to-Bac baculovirus expression system. Enzymatic reactions were carried out, and the metabolites were determined by ultra-performance...

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PMID: 34648813
DOI: 10.1016/j.cbi.2021.109700

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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