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Article

Functional assessment of the effects of CYP3A4 variants on acalabrutinib metabolism in vitro.

Chemico-biological interactions - 25 Aug 2021

Han Mingming, Qian Jianchang, Ye Zhize, Xu Renai, Chen Daoxing, Xie Saili, Cai Jianping, Hu Guoxin

Abstract excerpt

AIM: We aimed (i) to study the effects of genetic polymorphism of cytochrome P450 3A4 (CYP3A4) and drug interactions on acalabrutinib (ACA) metabolism and (ii) to investigate the mechanisms underlying the effects of CYP3A4 variants on the differential kinetic profiles of ACA and ibrutinib. METHOD: Recombinant human CYP3A4 and variants were expressed using a Bac-to-Bac baculovirus expression system. The cell...

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Identifiers

PMID: 34153224
DOI: 10.1016/j.cbi.2021.109559

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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