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Article

Functional characterization of cytochrome P450 2A6 allelic variants CYP2A615, CYP2A616, CYP2A621, and CYP2A622.

Drug metabolism and disposition: the biological fate of chemicals - 1 May 2010

Tiong Kai Hung, Yiap Beow Chin, Tan Eng Lai, Ismail Rusli, Ong Chin Eng

Abstract excerpt

Variation in CYP2A6 levels and activity can be attributed to genetic polymorphism and, thus, functional characterization of allelic variants is necessary to define the importance of CYP2A6 polymorphism in humans. The aim of the present study was to investigate the reported alleles CYP2A6*15, CYP2A6*16, CYP2A6*21, and CYP2A6*22, in terms of the functional consequences of their mutations on the enzyme catalytic...

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Identifiers

PMID: 20139165
DOI: 10.1124/dmd.109.031054

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