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Article

A single-copy Sleeping Beauty transposon mutagenesis screen identifies new PTEN-cooperating tumor suppressor genes.

Nature genetics - 1 May 2017

de la Rosa Jorge, Weber Julia, Friedrich Mathias Josef, Li Yilong, Rad Lena, Ponstingl Hannes, Liang Qi, de Quirós Sandra Bernaldo, Noorani Imran, Metzakopian Emmanouil, Strong Alexander, Li Meng Amy, Astudillo Aurora, Fernández-García María Teresa, Fernández-García María Soledad, Hoffman Gary J, Fuente Rocío, Vassiliou George S, Rad Roland, López-Otín Carlos, Bradley Allan, Cadiñanos Juan

Abstract excerpt

The overwhelming number of genetic alterations identified through cancer genome sequencing requires complementary approaches to interpret their significance and interactions. Here we developed a novel whole-body insertional mutagenesis screen in mice, which was designed for the discovery of Pten-cooperating tumor suppressors. Toward this aim, we coupled mobilization of a single-copy inactivating Sleeping Beauty...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 28319090
DOI: 10.1038/ng.3817
PMCID: PMC5409503

Genes

PTEN
AKAP13
CELF2
PARD3
WAC
ZBTB20

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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