Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A modified sleeping beauty transposon system that can be used to model a wide variety of human cancers in mice.

Cancer research - 15 Oct 2009

Dupuy Adam J, Rogers Laura M, Kim Jinsil, Nannapaneni Kishore, Starr Timothy K, Liu Pentao, Largaespada David A, Scheetz Todd E, Jenkins Nancy A, Copeland Neal G

Abstract excerpt

Recent advances in cancer therapeutics stress the need for a better understanding of the molecular mechanisms driving tumor formation. This can be accomplished by obtaining a more complete description of the genes that contribute to cancer. We previously described an approach using the Sleeping Beauty (SB) transposon system to model hematopoietic malignancies in mice. Here, we describe modifications of the SB...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Carcinoma, Hepatocellular
Share to Immunoenzyme Techniques

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Integrases

Share to Liver Neoplasms, Experimental

Share to Lymphoma, B-Cell

Share to Mice, Inbred C3H

Share to Monte Carlo Method

Share to Mutagenesis, Insertional

Source

Open in PubMed Open full text

Identifiers

PMID: 19808965
DOI: 10.1158/0008-5472.CAN-09-1135
PMCID: PMC3700628

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A modified sleeping beauty transposon system that can be used to model a wide variety of human cancers in mice.PMID 19808965Read ↗

Identification of cancer driver genes using Sleeping Beauty transposon mutagenesis.Semantic proximity Read ↗

Mammalian mutagenesis using a highly mobile somatic Sleeping Beauty transposon system.Semantic proximity Read ↗

A DNA transposon-based approach to validate oncogenic mutations in the mouse.Semantic proximity Read ↗

A transposon-based genetic screen in mice identifies genes altered in colorectal cancer.Semantic proximity Read ↗

Advances in functional genetic screening with transposons and CRISPR/Cas9 to illuminate cancer biology.Semantic proximity Read ↗

A single-copy Sleeping Beauty transposon mutagenesis screen identifies new PTEN-cooperating tumor suppressor genes.Semantic proximity Read ↗

Transposon mutagenesis disentangles osteosarcoma genetic drivers.Semantic proximity Read ↗

Mouse models for the discovery of colorectal cancer driver genes.Semantic proximity Read ↗

Transposon mutagenesis identifies cooperating genetic drivers during keratinocyte transformation and cutaneous squamous cell carcinoma progressionSemantic proximity Read ↗

Genetic Signature of Histiocytic Sarcoma Revealed by a Sleeping Beauty Transposon Genetic Screen in MiceSemantic proximity Read ↗

Cell of origin strongly influences genetic selection in a mouse model of T-ALL.Semantic proximity Read ↗

Transposon Mutagenesis Screen Identifies Potential Lung Cancer Drivers and CUL3 as a Tumor Suppressor.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.