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Article

A DNA transposon-based approach to validate oncogenic mutations in the mouse.

Proceedings of the National Academy of Sciences of the United States of America - 16 Dec 2008

Su Qin, Prosser Haydn M, Campos Lia S, Ortiz Mariaestela, Nakamura Takuro, Warren Madhuri, Dupuy Adam J, Jenkins Nancy A, Copeland Neal G, Bradley Allan, Liu Pentao

Abstract excerpt

Large-scale cancer genome projects will soon be able to sequence many cancer genomes to comprehensively identify genetic changes in human cancer. Genome-wide association studies have also identified putative cancer associated loci. Functional validation of these genetic mutations in vivo is becoming a challenge. We describe here a DNA transposon-based platform that permits us to explore the oncogenic potential of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 19064922
DOI: 10.1073/pnas.0807785105
PMCID: PMC2597691

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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