Article
Transposon Mutagenesis Screen Identifies Potential Lung Cancer Drivers and CUL3 as a Tumor Suppressor.
Molecular cancer research : MCR - 1 Aug 2015
Dorr Casey, Janik Callie, Weg Madison, Been Raha A, Bader Justin, Kang Ryan, Ng Brandon, Foran Lindsey, Landman Sean R, O'Sullivan M Gerard, Steinbach Michael, Sarver Aaron L, Silverstein Kevin A T, Largaespada David A, Starr Timothy K
Abstract excerpt
UNLABELLED: Non-small cell lung cancers (NSCLC) harbor thousands of passenger events that hide genetic drivers. Even highly recurrent events in NSCLC, such as mutations in PTEN, EGFR, KRAS, and ALK, are detected, at most, in only 30% of patients. Thus, many unidentified low-penetrant events are causing a significant portion of lung cancers. To detect low-penetrance drivers of NSCLC, a forward genetic screen was...
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