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Article

Increased insulin sensitivity in mice lacking collectrin, a downstream target of HNF-1alpha.

Molecular endocrinology (Baltimore, Md.) - 1 Jun 2009

Malakauskas Sandra M, Kourany Wissam M, Zhang Xiao Yin, Lu Danhong, Stevens Robert D, Koves Timothy R, Hohmeier Hans E, Muoio Deborah M, Newgard Christopher B, Le Thu H

Abstract excerpt

Collectrin is a downstream target of the transcription factor hepatocyte nuclear factor-1alpha (HNF-1alpha), which is mutated in maturity-onset diabetes of the young subtype 3 (MODY3). Evidence from transgenic mouse models with collectrin overexpression in pancreatic islets suggests divergent roles for collectrin in influencing beta-cell mass and insulin exocytosis. To clarify the function of collectrin in the...

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Identifiers

PMID: 19246514
DOI: 10.1210/me.2008-0274
PMCID: PMC2691681

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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