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Article

The HNF-1alpha-SNARE connection.

Diabetes, obesity & metabolism - 1 Nov 2007

Yamagata K, Nammo T, Sato Y, Saisho K, Shoda H, Fukui K

Abstract excerpt

Maturity-onset diabetes of the young (MODY) is a monogenic form of type 2 diabetes mellitus that is characterized by impairment of glucose-stimulated insulin secretion from pancreatic beta-cells. We previously reported that heterozygous mutations of the hepatocyte nuclear factor (HNF)-1alpha gene cause a form of MODY (MODY3). We have subsequently found that collectrin, a recently cloned kidney-specific gene of...

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Share to Diabetes Mellitus, Type 2
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Insulin-Secreting Cells

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Source

Identifiers

PMID: 17919177
DOI: 10.1111/j.1463-1326.2007.00773.x

Genes

SNAP25

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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The HNF-1alpha-SNARE connection.PMID 17919177Read ↗

Roles of HNF1α and HNF4α in pancreatic β-cells: lessons from a monogenic form of diabetes (MODY).Semantic proximity Read ↗

Increased insulin sensitivity in mice lacking collectrin, a downstream target of HNF-1alpha.Semantic proximity Read ↗

Hepatocyte nuclear factor-4alpha is essential for glucose-stimulated insulin secretion by pancreatic beta-cells.Semantic proximity Read ↗

The maturity-onset diabetes of the young (MODY1) transcription factor HNF4alpha regulates expression of genes required for glucose transport and metabolism.Semantic proximity Read ↗

HNF1A deficiency causes reduced calcium levels, accumulation of abnormal insulin granules and uncoupled insulin to C-peptide secretion in a stem cell model of MODY3Semantic proximity Read ↗

Genetic modifiers of the age at diagnosis of diabetes (MODY3) in carriers of hepatocyte nuclear factor-1alpha mutations map to chromosomes 5p15, 9q22, and 14q24.Semantic proximity Read ↗

HNF-4alpha: from MODY to late-onset type 2 diabetes.Semantic proximity Read ↗

Overexpression of dominant-negative mutant hepatocyte nuclear fctor-1 alpha in pancreatic beta-cells causes abnormal islet architecture with decreased expression of E-cadherin, reduced beta-cell proliferation, and diabetes.Semantic proximity Read ↗

Human stem cell model of <i>HNF1A</i> deficiency shows uncoupled insulin to C-peptide secretion with accumulation of abnormal insulin granulesSemantic proximity Read ↗

HNF1alpha controls renal glucose reabsorption in mouse and man.Semantic proximity Read ↗

Hepatocyte nuclear factor 1, a transcription factor at the crossroads of glucose homeostasis.Semantic proximity Read ↗

Tubular proteinuria in patients with HNF1α mutations: HNF1α drives endocytosis in the proximal tubule.Semantic proximity Read ↗

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