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Article

Silencing of the <i>Fibroblast growth factor 21</i> gene is an underlying cause of acinar cell injury in mice lacking MIST1

19 Feb 2014

Abstract excerpt

Fibroblast growth factor 21 (FGF21) is a key regulator of metabolism under conditions of stress such as starvation, obesity, and hypothermia. Rapid induction of FGF21 is also observed in experimental models of pancreatitis, and FGF21 reduces tissue damage observed in these models, suggesting a nonmetabolic function. Pancreatitis is a debilitating disease with significant morbidity that greatly increases the risk...

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PMID: 24549397
DOI: 10.1152/ajpendo.00559.2013

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