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Article

Genetic deletion of Wdr13 improves the metabolic phenotype of Lepr (db/db) mice by modulating AP1 and PPARγ target genes.

Diabetologia - 1 Feb 2015

Singh Vijay P, Gurunathan Chandrashekaran, Singh Sachin, Singh Bhavtaran, Lakshmi B Jyothi, Mishra Arun P, Kumar Satish

Abstract excerpt

AIM/HYPOTHESIS: Type 2 diabetes is a complex disease characterised by hyperglycaemia, hyperinsulinaemia, dyslipidaemia and insulin resistance accompanied by inflammation. Previously, we showed that mice lacking the Wdr13 gene had increased islet mass due to enhanced beta cell proliferation. We hypothesised that introgression of a Wdr13-null mutation, a beta cell-proliferative phenotype, into Lepr(db/db) mice, a...

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Source

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PMID: 25417213
DOI: 10.1007/s00125-014-3438-y

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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