Article
Beta-cell-targeted expression of a dominant-negative hepatocyte nuclear factor-1 alpha induces a maturity-onset diabetes of the young (MODY)3-like phenotype in transgenic mice.
Endocrinology - 1 Dec 2001
Hagenfeldt-Johansson K A, Herrera P L, Wang H, Gjinovci A, Ishihara H, Wollheim C B
Abstract excerpt
Mutations in the transcription factor hepatocyte nuclear factor-1 alpha (HNF-1 alpha) cause maturity-onset diabetes of the young 3, a severe form of diabetes characterized by pancreatic beta-cell dysfunction. We have used targeted expression of a dominant-negative mutant of HNF-1 alpha to specifically suppress HNF-1 alpha function in beta-cells of transgenic mice. We show that males expressing the mutant protein...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.