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Article

Men1 maintains exocrine pancreas homeostasis in response to inflammation and oncogenic stress.

Proceedings of the National Academy of Sciences of the United States of America - 24 Mar 2020

Wasylishen Amanda R, Sun Chang, Chau Gilda P, Qi Yuan, Su Xiaoping, Kim Michael P, Estrella Jeannelyn S, Lozano Guillermina

Abstract excerpt

A more comprehensive understanding of the molecular mechanisms underlying pancreatic diseases, including pancreatitis and cancer, is essential to improve clinical management. MEN1 has established roles in epigenetic regulation and tumor suppression in the endocrine pancreas; however, intriguing recent data suggest MEN1 may also function in the exocrine pancreas. Using physiologically relevant genetic mouse...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 32156729
DOI: 10.1073/pnas.1920017117
PMCID: PMC7104337

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