Article
Overexpression of dominant-negative mutant hepatocyte nuclear fctor-1 alpha in pancreatic beta-cells causes abnormal islet architecture with decreased expression of E-cadherin, reduced beta-cell proliferation, and diabetes.
Diabetes - 1 Jan 2002
Yamagata Kazuya, Nammo Takao, Moriwaki Makoto, Ihara Arisa, Iizuka Katsumi, Yang Qin, Satoh Tomomi, Li Ming, Uenaka Rikako, Okita Kohei, Iwahashi Hiromi, Zhu Qian, Cao Yang, Imagawa Akihisa, Tochino Yoshihiro, Hanafusa Toshiaki, Miyagawa Jun-ichiro, Matsuzawa Yuji
Abstract excerpt
One subtype of maturity-onset diabetes of the young (MODY)-3 results from mutations in the gene encoding hepatocyte nuclear factor (HNF)-1 alpha. We generated transgenic mice expressing a naturally occurring dominant-negative form of human HNF-1 alpha (P291fsinsC) in pancreatic beta-cells. A progressive hyperglycemia with age was seen in these transgenic mice, and the mice developed diabetes with impaired...
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