Article

Deletion of <i>Nudt19</i> Increases Albuminuria in Mice Fed a High Fat Diet

2025-03-25

Abstract excerpt

Nudix hydrolase 19 (NUDT19) is a peroxisomal enzyme that hydrolyzes CoA species at the phosphodiester bond and has been linked to peroxisomal dysfunction in the context of diabetic kidney disease. Despite its predominant expression in mouse kidneys, the physiological role of NUDT19 remains poorly understood. To investigate its function under metabolic stress, we fed Nudt19 -/- mice a high fat diet (HFD) for 15 we...

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Literature Corpus work: 54628302-d6bc-5527-92b6-900e8f775002
DOI: 10.1101/2025.03.22.644727

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