Alteration from T- to B-cell tropism reduces thymic atrophy and cytocidal effects in thymocytes but not neurovirulence induced by ts1, a mutant of Moloney murine leukemia virus TB.

doi:10.1073/pnas.88.20.8991

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Article

Alteration from T- to B-cell tropism reduces thymic atrophy and cytocidal effects in thymocytes but not neurovirulence induced by ts1, a mutant of Moloney murine leukemia virus TB.

Proceedings of the National Academy of Sciences of the United States of America - 15 Oct 1991

Wong P K, Szurek P F, Floyd E, Saha K, Brooks B R

Abstract excerpt

The ts1 mutant of Moloney murine leukemia virus TB causes degenerative neurologic and immunologic disease in mice, characterized by development of spongiform encephalomyelopathy resulting in hindlimb paralysis, marked thymic atrophy associated with immunodeficiency, and generalized body wasting. To investigate the pathogenesis of the thymic atrophy caused by ts1, we constructed a chimeric virus, ts1-Cas(NS), in...

Topics

Animals
Atrophy
B-Lymphocytes
Base Sequence
Cell Death
Cell Line
Chimera
Cloning, Molecular
Corticosterone
DNA, Viral
Genome, Viral

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mice

Molecular Sequence Data

Moloney murine leukemia virus

Mutation

Paralysis

Plasmids

Repetitive Sequences, Nucleic Acid

Source

Open in PubMed Open full text

Identifiers

PMID: 1924361
DOI: 10.1073/pnas.88.20.8991
PMCID: PMC52637

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1924361-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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