Article
Temporal lymphoreticular changes caused by ts1, a paralytogenic mutant of Moloney murine leukemia virus TB.
Laboratory investigation; a journal of technical methods and pathology - 1 Apr 1992
Stoica G, Floyd E, Illanes O, Wong P K
Abstract excerpt
Inoculation of newborn FVB/N mice with ts1, a mutant of Moloney murine leukemia virus TB, induced severe thymic atrophy, spongiform polioencephalomyelopathy, and fatal posterior paralysis of the affected mice 35-40 days after inoculation. During the early course of infection viral replication was found in the spleen and, more importantly, within the thymus. Of these organs, the thymus was affected most severely...
Topics
- Animals
- Animals, Newborn
- Atrophy
- Endothelium, Vascular
- Leukemia, Experimental
- Liver
- Lymph Nodes
- Mice
- Moloney murine leukemia virus
- Mutation
- Paralysis