ts1-Induced spongiform encephalomyelopathy: physical forms of high-mobility DNA in spinal cord tissues of paralyzed mice are products of premature termination of reverse transcription.

doi:10.1128/JVI.70.4.2230-2236.1996

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Article

ts1-Induced spongiform encephalomyelopathy: physical forms of high-mobility DNA in spinal cord tissues of paralyzed mice are products of premature termination of reverse transcription.

Journal of virology - 1 Apr 1996

Szurek P F, Brooks B R

Abstract excerpt

ts1 is a temperature-sensitive mutant of Moloney murine leukemia virus that causes hind-limb paralysis in mice. In tissues of the central nervous systems of paralyzed moribund FVB/N mice, a major component of the unintegrated viral DNA of ts1 consists of highly mobile physical forms of viral-spec...

Topics

Animals
Cell Line
Central Nervous System Diseases
DNA
DNA Probes
DNA, Antisense
DNA, Viral
Mice
Moloney murine leukemia virus
Mutation
Paralysis
Repetitive Sequences, Nucleic Acid
Retroviridae Infections
Transcription, Genetic
Tumor Virus Infections

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Identifiers

PMID: 8642647
DOI: 10.1128/JVI.70.4.2230-2236.1996
PMCID: PMC190063

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8642647-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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