Neurodegeneration induced by MoMuLV-ts1 and increased expression of Fas and TNF-alpha in the central nervous system.

doi:10.1016/s0006-8993(97)00929-3

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Article

Neurodegeneration induced by MoMuLV-ts1 and increased expression of Fas and TNF-alpha in the central nervous system.

Brain research - 1 Jan 1998

Choe W, Stoica G, Lynn W, Wong P K

Abstract excerpt

Infection of neonatal mice with ts1, the neuropathogenic mutant of the Moloney murine leukemia virus, results in motor neuronal death in the brainstem and the spinal cord, with gliosis and demyelination, but no inflammatory cell infiltration into the CNS. To evaluate the possible mechanism(s) of...

Topics

Animals
Cell Death
Central Nervous System Diseases
Fas Ligand Protein
Ligands
Membrane Glycoproteins
Mice
Mice, Inbred Strains
Moloney murine leukemia virus
Mutation
Nerve Degeneration
Prion Diseases
Tumor Necrosis Factor-alpha
fas Receptor

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