ts1, a temperature-sensitive mutant of Moloney murine leukemia virus TB, can infect both CD4+ and CD8+ T cells but requires CD4+ T cells in order to cause paralysis and immunodeficiency.

Abstract excerpt

When neonatal FVB/N mice were inoculated with ts1, a temperature-sensitive mutant of Moloney murine leukemia virus TB, they developed a progressive bilateral hindlimb paralysis and immunodeficiency leading to death 4 to 6 weeks after inoculation. T lymphocytes have been shown to be primarily responsible for this ts1-induced syndrome. Here we compare the role played by each subset of T lymphocytes, i.e., CD4+ and...

Topics

• Animals
• Animals, Newborn
• Base Sequence
• CD4 Antigens
• CD4-Positive T-Lymphocytes
• CD8 Antigens
• Hindlimb
• Hypergammaglobulinemia
• Immunocompetence
• Leukemia, Experimental
• Lymphocyte Depletion