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Article

Murine leukemia virus induced central nervous system diseases.

Leukemia - 1 Jan 1992

Wong P K, Shikova E, Lin Y C, Saha K, Szurek P F, Stoica G, Madden R, Brooks B R

Abstract excerpt

The ts1 mutant of Moloney murine leukemia virus TB (MoMuLV-TB) causes a degenerative neurologic and immunologic disease in mice characterized by development of spongiform encephalomyelopathy that results in hind-limb paralysis, marked thymic atrophy associated with immunodeficiency, and generalized body wasting. T cells, particularly CD4+ helper T cells, play a key role in the pathogenesis of the disease induced...

Topics

Animals
Brain Neoplasms
Genes, env
Leukemia, Experimental
Mice
Mice, Inbred BALB C
Moloney murine leukemia virus
Mutation
Spleen
T-Lymphocytes
Viral Envelope Proteins
Virus Replication

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 1602815

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1602815-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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