Article
T, not B, lymphocytes are required for immunodeficiency and paralysis induced by ts1, a mutant of Moloney murine leukemia virus-TB.
Virology - 1 Aug 1991
Saha K, Wong P K
Abstract excerpt
BALB/c mice when injected as newborn with ts1, a temperature-sensitive mutant of Moloney murine leukemia virus-TB, developed a fatal hindlimb paralysis and immunodeficiency. This disease induction was prevented, to a great extent, by transient depletion of the peripheral T lymphocytes during the early course of infection by using anti-Thy 1.2 antibody. FVB/N mice, which are highly susceptible to ts1, but express...
Topics
- Animals
- B-Lymphocytes
- Fluorescent Antibody Technique
- Mice
- Mice, Inbred BALB C
- Moloney murine leukemia virus
- Murine Acquired Immunodeficiency Syndrome
- Mutation
- T-Lymphocytes
- Virus Replication