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Article

SCAMP5 links endoplasmic reticulum stress to the accumulation of expanded polyglutamine protein aggregates via endocytosis inhibition.

The Journal of biological chemistry - 24 Apr 2009

Noh Jee-Yeon, Lee Huikyong, Song Sungmin, Kim Nam Soon, Im Wooseok, Kim Manho, Seo Hyemyung, Chung Chul-Woong, Chang Jae-Woong, Ferrante Robert J, Yoo Young-Jun, Ryu Hoon, Jung Yong-Keun

Abstract excerpt

Accumulation of expanded polyglutamine proteins is considered to be a major pathogenic biomarker of Huntington disease. We isolated SCAMP5 as a novel regulator of cellular accumulation of expanded polyglutamine track protein using cell-based aggregation assays. Ectopic expression of SCAMP5 augments the formation of ubiquitin-positive and detergent-resistant aggregates of mutant huntingtin (mtHTT). Expression of...

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Identifiers

PMID: 19240033
DOI: 10.1074/jbc.M807620200
PMCID: PMC2670137

Genes

SCAMP5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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