Article

Epsin2, a novel target for multiple system atrophy therapy via α-synuclein/FABP7 propagation

2022-06-17

Abstract excerpt

<h4>SUMMARY</h4> Multiple system atrophy (MSA) is a neurodegenerative disease showing accumulation of misfolded α-synuclein and myelin disruption. However, the mechanism how α-synuclein (α-syn) accumulate in MSA brain remains unclear. Here, we identify the protein epsin-2 as a novel target for MSA therapy via controlling α-synuclein accumulation. In MSA mouse model, PLP-hαSyn transgenic mice and FABP7/α-syn heter...

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Literature Corpus work: da4532f7-b1c5-5461-9c4a-9f7862857504
DOI: 10.1101/2022.06.16.496509

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