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Article

IRE1 plays an essential role in ER stress-mediated aggregation of mutant huntingtin via the inhibition of autophagy flux.

Human molecular genetics - 1 Jan 2012

Lee Huikyong, Noh Jee-Yeon, Oh Yumin, Kim Youngdoo, Chang Jae-Woong, Chung Chul-Woong, Lee Soon-Tae, Kim Manho, Ryu Hoon, Jung Yong-Keun

Abstract excerpt

Huntington's disease (HD), an inherited neurodegenerative disorder, is caused by an expansion of cytosine-adenine-guanine repeats in the huntingtin gene. The aggregation of mutant huntingtin (mtHTT) and striatal cell loss are representative features to cause uncontrolled movement and cognitive defect in HD. However, underlying mechanism of mtHTT aggregation and cell toxicity remains still elusive. Here, to find...

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Identifiers

PMID: 21954231
DOI: 10.1093/hmg/ddr445

Genes

TRAF2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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