Article

TDP43 aggregation at ER-exit sites impairs ER-to-Golgi transport

2024-01-24

Abstract excerpt

Protein aggregation plays key roles in age-related degenerative diseases, but how different proteins coalesce to form inclusions that vary in composition, morphology, molecular dynamics and confer physiological consequences is poorly understood. Here we employed a general reporter based on mutant Hsp104 to identify proteins forming aggregates in human cells under common proteotoxic stress. Over 300 proteins were i...

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Literature Corpus work: a49bdca0-7cff-5142-98ba-36f273f68104
DOI: 10.1101/2024.01.24.576891

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