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G3BP1-dependent mechanism suppressing protein aggregation in Huntington's models and its demise upon stress granule assembly.

Human molecular genetics - 5 May 2023

Gutiérrez-Garcia Ricardo, Koyuncu Seda, Hommen Franziska, Bilican Saygın, Lee Hyun Ju, Fatima Azra, Vilchez David

Abstract excerpt

Stress granules are membrane-less ribonucleoprotein organelles that assemble upon exposure to stress conditions, but rapidly disassemble upon removal of stress. However, chronic stress can lead to persistent stress granules, a feature of distinct age-related neurodegenerative disorders. Among them, Huntington's disease (HD), which is caused by mutant expansion of the polyglutamine (polyQ) repeats of huntingtin...

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PMID: 36611004
DOI: 10.1093/hmg/ddac304
PMCID: PMC10355105

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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