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Article

Huntingtin has a membrane association signal that can modulate huntingtin aggregation, nuclear entry and toxicity.

Human molecular genetics - 1 Nov 2007

Atwal Randy Singh, Xia Jianrun, Pinchev Deborah, Taylor Jillian, Epand Richard M, Truant Ray

Abstract excerpt

Huntington's disease is caused by an expanded polyglutamine tract in huntingtin protein, leading to accumulation of huntingtin in the nuclei of striatal neurons. The 18 amino-acid amino-terminus of huntingtin is an amphipathic alpha helical membrane-binding domain that can reversibly target to vesicles and the endoplasmic reticulum (ER). The association of huntingtin to the ER is affected by ER stress. A single...

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Identifiers

PMID: 17704510
DOI: 10.1093/hmg/ddm217

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Huntingtin has a membrane association signal that can modulate huntingtin aggregation, nuclear entry and toxicity.PMID 17704510Read ↗

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