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How Do Post-Translational Modifications Influence the Pathomechanistic Landscape of Huntington's Disease? A Comprehensive Review.

International journal of molecular sciences - 16 Jun 2020

Lontay Beata, Kiss Andrea, Virág László, Tar Krisztina

Abstract excerpt

Huntington's disease (HD) is an autosomal dominant inherited neurodegenerative disorder characterized by the loss of motor control and cognitive ability, which eventually leads to death. The mutant huntingtin protein (HTT) exhibits an expansion of a polyglutamine repeat. The mechanism of pathogenesis is still not fully characterized; however, evidence suggests that post-translational modifications (PTMs) of HTT...

Topics

Humans
Huntingtin Protein
Huntington Disease
Mutation
Protein Folding
Protein Processing, Post-Translational
Signal Transduction

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 32560122
DOI: 10.3390/ijms21124282
PMCID: PMC7349273

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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