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Article

Mutant Huntingtin Is Secreted via a Late Endosomal/Lysosomal Unconventional Secretory Pathway.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 13 Sept 2017

Trajkovic Katarina, Jeong Hyunkyung, Krainc Dimitri

Abstract excerpt

Huntington's disease (HD) is an autosomal-dominant neurodegenerative disorder caused by the expansion of a CAG triplet in the gene encoding for huntingtin (Htt). The resulting mutant protein (mHtt) with extended polyglutamine (polyQ) sequence at the N terminus leads to neuronal degeneration both in a cell-autonomous and a non-cell-autonomous manner. Recent studies identified mHtt in the extracellular environment...

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Identifiers

PMID: 28821645
DOI: 10.1523/JNEUROSCI.0118-17.2017
PMCID: PMC5597981

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