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Article

PIAS1 Regulates Mutant Huntingtin Accumulation and Huntington's Disease-Associated Phenotypes In Vivo.

Neuron - 4 May 2016

Ochaba Joseph, Monteys Alex Mas, O'Rourke Jacqueline G, Reidling Jack C, Steffan Joan S, Davidson Beverly L, Thompson Leslie M

Abstract excerpt

The disruption of protein quality control networks is central to pathology in Huntington's disease (HD) and other neurodegenerative disorders. The aberrant accumulation of insoluble high-molecular-weight protein complexes containing the Huntingtin (HTT) protein and SUMOylated protein corresponds to disease manifestation. We previously identified an HTT-selective E3 SUMO ligase, PIAS1, that regulates HTT...

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Identifiers

PMID: 27146268
DOI: 10.1016/j.neuron.2016.03.016
PMCID: PMC4942306

Genes

PIAS1
HTT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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