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Article

<i>INK4</i> locus of the tumor-resistant rodent, the naked mole rat, expresses a functional p15/p16 hybrid isoform

30 Dec 2014

Abstract excerpt

The naked mole rat (Heterocephalus glaber) is a long-lived and tumor-resistant rodent. Tumor resistance in the naked mole rat is mediated by the extracellular matrix component hyaluronan of very high molecular weight (HMW-HA). HMW-HA triggers hypersensitivity of naked mole rat cells to contact inhibition, which is associated with induction of the INK4 (inhibitors of cyclin dependent kinase 4) locus leading to...

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PMID: 25550505
DOI: 10.1073/pnas.1418203112

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