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Article

Expression of <i>p16</i><sup><i>INK4a</i></sup> in peripheral blood T‐cells is a biomarker of human aging

22 May 2009

Abstract excerpt

Expression of the p16(INK4a) tumor suppressor sharply increases with age in most mammalian tissues, and contributes to an age-induced functional decline of certain self-renewing compartments. These observations have suggested that p16(INK4a) expression could be a biomarker of mammalian aging. To translate this notion to human use, we determined p16(INK4a) expression in cellular fractions of human whole blood, and...

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PMID: 19485966
DOI: 10.1111/j.1474-9726.2009.00489.x

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