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Article

Genetic epistasis of IL23/IL17 pathway genes in Crohn's disease.

Inflammatory bowel diseases - 1 Jun 2009

McGovern Dermot P B, Rotter Jerome I, Mei Ling, Haritunians Talin, Landers Carol, Derkowski Carrie, Dutridge Deb, Dubinsky Marla, Ippoliti Andy, Vasiliauskas Eric, Mengesha Emebet, King Lily, Pressman Sheila, Targan Stephan R, Taylor Kent D

Abstract excerpt

BACKGROUND: The IL23/IL17 pathway is pivotal in the development of chronic mucosal inflammation seen in Crohn's disease (CD). Genetic variants in the IL23R and IL12B have been associated with CD susceptibility. We investigated 10 genes within the IL23/IL17 pathway in a case-control study of 763 CD cases and 254 healthy controls. METHODS: We identified a novel association in haplotypes in IL17A (empirical P =...

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Identifiers

PMID: 19235914
DOI: 10.1002/ibd.20855
PMCID: PMC2916929

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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