Article
A genome-wide association study identifies IL23R as an inflammatory bowel disease gene.
Science (New York, N.Y.) - 1 Dec 2006
Duerr Richard H, Taylor Kent D, Brant Steven R, Rioux John D, Silverberg Mark S, Daly Mark J, Steinhart A Hillary, Abraham Clara, Regueiro Miguel, Griffiths Anne, Dassopoulos Themistocles, Bitton Alain, Yang Huiying, Targan Stephan, Datta Lisa Wu, Kistner Emily O, Schumm L Philip, Lee Annette T, Gregersen Peter K, Barmada M Michael, Rotter Jerome I, Nicolae Dan L, Cho Judy H
Abstract excerpt
The inflammatory bowel diseases Crohn's disease and ulcerative colitis are common, chronic disorders that cause abdominal pain, diarrhea, and gastrointestinal bleeding. To identify genetic factors that might contribute to these disorders, we performed a genome-wide association study. We found a highly significant association between Crohn's disease and the IL23R gene on chromosome 1p31, which encodes a subunit of...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.