Article
Contribution of the novel inflammatory bowel disease gene IL23R to disease susceptibility and phenotype.
Inflammatory bowel diseases - 1 Sept 2007
Cummings J R Fraser, Ahmad Tariq, Geremia Alessandra, Beckly John, Cooney Rachel, Hancock Laura, Pathan Saad, Guo Changcun, Cardon Lon R, Jewell Derek P
Abstract excerpt
BACKGROUND: A North American genome-wide single nucleotide polymorphism (SNP) association study identified IL23R as a novel inflammatory bowel disease (IBD) susceptibility gene. Association was reported with multiple risk variants in the centromeric portion of IL23R in 3 large independent cohorts. The aims of this study were to replicate the association of IL23R with Crohn's disease (CD), examine subphenotype...
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