Article
Diverse genome-wide association studies associate the IL12/IL23 pathway with Crohn Disease.
American journal of human genetics - 1 Mar 2009
Wang Kai, Zhang Haitao, Kugathasan Subra, Annese Vito, Bradfield Jonathan P, Russell Richard K, Sleiman Patrick M A, Imielinski Marcin, Glessner Joseph, Hou Cuiping, Wilson David C, Walters Thomas, Kim Cecilia, Frackelton Edward C, Lionetti Paolo, Barabino Arrigo, Van Limbergen Johan, Guthery Stephen, Denson Lee, Piccoli David, Li Mingyao, Dubinsky Marla, Silverberg Mark, Griffiths Anne, Grant Struan F A, Satsangi Jack, Baldassano Robert, Hakonarson Hakon
Abstract excerpt
Previous genome-wide association (GWA) studies typically focus on single-locus analysis, which may not have the power to detect the majority of genuinely associated loci. Here, we applied pathway analysis using Affymetrix SNP genotype data from the Wellcome Trust Case Control Consortium (WTCCC) and uncovered significant association between Crohn Disease (CD) and the IL12/IL23 pathway, harboring 20 genes (p = 8 x...
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