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Article

Requirement of Mis6 centromere connector for localizing a CENP-A-like protein in fission yeast.

Science (New York, N.Y.) - 23 Jun 2000

Takahashi K, Chen E S, Yanagida M

Abstract excerpt

Mammalian kinetochores contain the centromere-specific histone H3 variant CENP-A, whose incorporation into limited chromosomal regions may be important for centromere function and chromosome segregation during mitosis. However, regulation of CENP-A localization and its role have not been clear. H...

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Identifiers

PMID: 10864871
DOI: 10.1126/science.288.5474.2215

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-10864871-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

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Click a neighbor to travelStep 1 · 12 closest

Requirement of Mis6 centromere connector for localizing a CENP-A-like protein in fission yeast.PMID 10864871Read ↗

Mis16 and Mis18 are required for CENP-A loading and histone deacetylation at centromeres.Semantic proximity Read ↗

Sim4: a novel fission yeast kinetochore protein required for centromeric silencing and chromosome segregation.Semantic proximity Read ↗

A NASP (N1/N2)-related protein, Sim3, binds CENP-A and is required for its deposition at fission yeast centromeres.Semantic proximity Read ↗

Fission yeast Scm3: A CENP-A receptor required for integrity of subkinetochore chromatin.Semantic proximity Read ↗

Heterochromatin and RNAi regulate centromeres by protecting CENP-A from ubiquitin-mediated degradation.Semantic proximity Read ↗

The chromodomain protein Swi6: a key component at fission yeast centromeres.Semantic proximity Read ↗

Distinct centromere domain structures with separate functions demonstrated in live fission yeast cells.Semantic proximity Read ↗

The CENP-H-I complex is required for the efficient incorporation of newly synthesized CENP-A into centromeres.Semantic proximity Read ↗

The conserved Spc7 protein is required for spindle integrity and links kinetochore complexes in fission yeast.Semantic proximity Read ↗

The CENP-A N-tail confers epigenetic stability to centromeres via the CENP-T branch of the CCAN in fission yeast.Semantic proximity Read ↗

Fta2, an essential fission yeast kinetochore component, interacts closely with the conserved Mal2 protein.Semantic proximity Read ↗

Heterochromatin integrity affects chromosome reorganization after centromere dysfunction.Semantic proximity Read ↗

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