Article
BDNF Val 66 Met and 5-HTTLPR genotype moderate the impact of early psychosocial adversity on plasma brain-derived neurotrophic factor and depressive symptoms: a prospective study.
European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology - 1 Aug 2013
Buchmann Arlette F, Hellweg Rainer, Rietschel Marcella, Treutlein Jens, Witt Stephanie H, Zimmermann Ulrich S, Schmidt Martin H, Esser Günter, Banaschewski Tobias, Laucht Manfred, Deuschle Michael
Abstract excerpt
Recent studies have emphasized an important role for neurotrophins, such as brain-derived neurotrophic factor (BDNF), in regulating the plasticity of neural circuits involved in the pathophysiology of stress-related diseases. The aim of the present study was to examine the interplay of the BDNF Val⁶⁶Met and the serotonin transporter promoter (5-HTTLPR) polymorphisms in moderating the impact of early-life...
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