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Article

Association of adverse childhood environment and 5-HTTLPR Genotype with late-life depression.

The Journal of clinical psychiatry - 1 Sept 2009

Ritchie Karen, Jaussent Isabelle, Stewart Robert, Dupuy Anne-Marie, Courtet Philippe, Ancelin Marie-Laure, Malafosse Alain

Abstract excerpt

OBJECTIVE: Neurobiological and clinical studies suggest that childhood maltreatment may result in functional and structural nervous system changes that predispose the individual to depression. This vulnerability appears to be modulated by a polymorphism in the serotonin gene-linked promoter region (5-HTTLPR). Little is known, however, about the persistence of this vulnerability across the life span, although...

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Identifiers

PMID: 19573496
DOI: 10.4088/JCP.08m04510
PMCID: PMC3078522

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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