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Article

Interaction between specific forms of childhood maltreatment and the serotonin transporter gene (5-HTT) in recurrent depressive disorder.

Journal of affective disorders - 15 Feb 2013

Fisher Helen L, Cohen-Woods Sarah, Hosang Georgina M, Korszun Ania, Owen Mike, Craddock Nick, Craig Ian W, Farmer Anne E, McGuffin Peter, Uher Rudolf

Abstract excerpt

BACKGROUND: There is inconsistent evidence of interaction between stressful events and a serotonin transporter promoter polymorphism (5-HTTLPR) in depression. Recent studies have indicated that the moderating effect of 5-HTTLPR may be strongest when adverse experiences have occurred in childhood and the depressive symptoms persist over time. However, it is unknown whether this gene-environment interaction is...

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Source

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Identifiers

PMID: 22840631
DOI: 10.1016/j.jad.2012.05.032
PMCID: PMC3825663

Genes

HTT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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