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Article

Three-way interaction effect of 5-HTTLPR, BDNF Val66Met, and childhood adversity on depression: a replication study.

European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology - 1 Oct 2013

Comasco Erika, Åslund Cecilia, Oreland Lars, Nilsson Kent W

Abstract excerpt

Both the serotonin transporter linked promoter region (5-HTTLPR) and the brain-derived neurotrophic factor (BDNF) Val66Met polymorphisms have been shown to interact with unfavourable environment in relation to depression symptoms and to depression diagnosis. Several attempts have been made to study a three-way interaction effect of these factors on depression, however with contradictory results. We aimed to test...

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Source

Identifiers

PMID: 23481907
DOI: 10.1016/j.euroneuro.2013.01.010

Genes

BDNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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