Genetic epistasis between the brain-derived neurotrophic factor Val66Met polymorphism and the 5-HTT promoter polymorphism moderates the susceptibility to depressive disorders after childhood abuse.

doi:10.1016/j.pnpbp.2011.09.010

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Article

Genetic epistasis between the brain-derived neurotrophic factor Val66Met polymorphism and the 5-HTT promoter polymorphism moderates the susceptibility to depressive disorders after childhood abuse.

Progress in neuro-psychopharmacology & biological psychiatry - 30 Mar 2012

Grabe Hans Jörgen, Schwahn Christian, Mahler Jessie, Appel Katja, Schulz Andrea, Spitzer Carsten, Fenske Kristin, Barnow Sven, Freyberger Harald Jürgen, Teumer Alexander, Petersmann Astrid, Biffar Reiner, Rosskopf Dieter, John Ulrich, Völzke Henry

Abstract excerpt

BACKGROUND: Based on biological interactions between the serotonergic system and the brain-derived neurotrophic factor (BDNF), BDNF is a plausible candidate for a gene-gene-environment interaction moderating the interaction between the s/l- promoter polymorphism of the serotonin transporter (5-HTTLPR) and childhood abuse. We tested the hypothesis of a three-way interaction with respect to depressive symptoms....

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Identifiers

PMID: 21996278
DOI: 10.1016/j.pnpbp.2011.09.010

Genes

BDNF
HTT

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Source receipt: pubmed, retrieved 7 Sept 2026.

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