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Article

The moderation by the serotonin transporter gene of environmental adversity in the aetiology of mental illness: review and methodological analysis.

Molecular psychiatry - 1 Feb 2008

Uher R, McGuffin P

Abstract excerpt

Gene-environmental interaction (G x E) between a common functional polymorphism in the promoter region of the serotonin transporter gene (5-HTT) and environmental adversity on the onset of depression in humans has been found in fifteen independent studies. It is supported by evidence from animal experiments, pharmacological challenge and neuroimaging investigations. However, negative findings have been reported...

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Source

Identifiers

PMID: 17700575
DOI: 10.1038/sj.mp.4002067

Genes

HTT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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