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Article

Interactive effect of stressful life events and the serotonin transporter 5-HTTLPR genotype on posttraumatic stress disorder diagnosis in 2 independent populations.

Archives of general psychiatry - 1 Nov 2009

Xie Pingxing, Kranzler Henry R, Poling James, Stein Murray B, Anton Raymond F, Brady Kathleen, Weiss Roger D, Farrer Lindsay, Gelernter Joel

Abstract excerpt

CONTEXT: The 5-HTTLPR polymorphism in the promoter region of the serotonin transporter gene (SLC6A4) has been found to moderate several categories of emotional response after stressful life events. Previous studies generally focused on its effect on depressive symptoms; little is known about its moderation of the development of posttraumatic stress disorder (PTSD). OBJECTIVE: To examine the effects of childhood...

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Source

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Identifiers

PMID: 19884608
DOI: 10.1001/archgenpsychiatry.2009.153
PMCID: PMC2867334

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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