Article
Moderation of adult depression by the serotonin transporter promoter variant (5-HTTLPR), childhood abuse and adult traumatic events in a general population sample.
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics - 1 Apr 2012
Grabe Hans Jörgen, Schwahn Christian, Mahler Jessie, Schulz Andrea, Spitzer Carsten, Fenske Kristin, Appel Katja, Barnow Sven, Nauck Matthias, Schomerus Georg, Biffar Reiner, Rosskopf Dieter, John Ulrich, Völzke Henry, Freyberger Harald Jürgen
Abstract excerpt
The impact of the promoter polymorphisms of the serotonin transporter (5-HTTLPR) on mood has been studied by two-way interaction models comprising one environmental factor and genotype variants. However, childhood abuse is assumed to be associated with different psychobiological long-term effects than adult traumatic events. Both types of trauma may interact on an individual basis throughout the lifespan...
Topics
- Adult
- Aged
- Aged, 80 and over
- Child
- Child Abuse
- Depression
- Female
- Genetic Predisposition to Disease
- Genetics, Population